Synthesis and Antimicrobial Activity of Some Novel Thiazolidine-2,4-dione Derivatives

Mentese A., Ceylan-Unlusoy M., BOZDAĞ DÜNDAR O., ALTANLAR N., Ertan R.

ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, cilt.59, sa.12, ss.659-665, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Sayı: 12
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1055/s-0031-1296456
  • Dergi Adı: ARZNEIMITTELFORSCHUNG-DRUG RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Index Chemicus (IC)
  • Sayfa Sayıları: ss.659-665
  • Anahtar Kelimeler: Antimicrobial activity, Thiazoles, Thiazolidine-2,4-diones, Triazoles, IN-VITRO, METHICILLIN-RESISTANT, BIOLOGICAL EVALUATION, ANTIBIOTICS, BINDING
  • Ankara Üniversitesi Adresli: Evet

Özet

In this study, a series of phenylethylsulfanyl-1,3-thiazolo-thiazolidine-2,4-dione derivatives (VII a-f, VIII a-f) and 5-methyl-[1,2,4]triazolyl-sulfanyl-1,3-thiazolo-thiazolidine-2,4-dione derivatives (IXa-f, Xa-f) were synthesized and evaluated for their antibacterial and antifungal activities against S. aureus (ATCC 25923), methicillin resistant S. aureus (MRSA ATCC 43300), B. subtilis (ATCC 6633), E. coli (ATCC 23556) and C. albicans (ATCC10145). All the compounds were found active against used bacteria.