Synthesis and biological activity of some new benzoxazoles

ARPACI Ö., YILDIZ İ., Oezkan S., Kaynak F., Aki-Sener E., Yalcin I.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, cilt.43, sa.7, ss.1423-1431, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 7
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.ejmech.2007.09.023
  • Dergi Adı: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1423-1431
  • Anahtar Kelimeler: benzoxazoles, antifungal activity, antibacterial activity, RESISTANCE
  • Ankara Üniversitesi Adresli: Evet

Özet

The synthesis and antimicrobial activity of a new series of 5-ethylsulphonyl-2-(substituted-phenyl/substituted-benzyl and/or phenylethyl)benzoxazole derivatives (3a-3t) except 3a, 3g, 3h, 3k [R.S. Pottorf, N.K. Chadha, M. Katkevies, V. Ozola, E. Suna, H. Ghane, T. Regberg, M.R. Player, Tetrahedron Lett. 44 (1) (2003) 175] were described. The in vitro antimicrobial activity of the compounds was determined against some Gram-positive, Gram-negative bacteria, a fungi Candida albicans and their drug-resistant isolates in comparison with standard drugs. Antimicrobial results indicated that the synthesized compounds possessed a broad spectrum of activity with MIC values 250-7.81 mu g/ml. While all compounds are less potent than fluconazole against C. albicans, most of them are more potent than fluconazole against C. albicans isolate. (c) 2007 Elsevier Masson SAS. All rights reserved.