Thermoresponsive poly (N-vinylcaprolactam)-g-galactosylated chitosan hydrogel: synthesis, characterization, and controlled release properties

DURKUT S.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, vol.68, no.17, pp.1034-1047, 2019 (SCI-Expanded, Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 68 Issue: 17
  • Publication Date: 2019
  • Doi Number: 10.1080/00914037.2018.1525546
  • Journal Name: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1034-1047
  • Keywords: Graft copolymer, galactosylated chitosan, pH responsive polymer, PNVCL, thermosensitive polymer, POLY(ACRYLIC ACID)-GRAFT-POLY(VINYLIDENE FLUORIDE), GALACTOSYLATED CHITOSAN, N-ISOPROPYLACRYLAMIDE, INJECTABLE HYDROGELS, RESPONSIVE POLYMERS, IN-VITRO, POLY(N-ISOPROPYLACRYLAMIDE), POLY(N-VINYLCAPROLACTAM), NANOPARTICLES, SCAFFOLDS
  • Ankara University Affiliated: Yes

Abstract

A dual (thermo- and pH-) responsive hybrid copolymer, poly(N-vinylcaprolactam) grafted galactosylated chitosan (PNVCL-g-GC) was synthesized by EDC/NHS crosslinking. PNVCL-g-GC exhibited a temperature-dependent phase change (LCST) at 32 degrees C in aqueous solutions. PNVCL-g-GC hydrogel scaffold was fabricated by freeze-drying, and evaluated as a delivery vehicle dependent on environmental pH and temperature. PNVCL-g-GC was characterized using ATR-FTIR, 1H-NMR, DSC, TGA, rheometry, and SEM. The swelling degree increased by the decrease both in temperature and pH. A faster BSA release was observed at 40 degrees C and at pH 7.2 from the cytocompatible and hemocompatible copolymer.