Radical scavenging capacities of some thiazolylthiazolidine-2,4-dione derivatives

BOZDAĞ DÜNDAR O., ÇOBAN T., Ceylan-Ünlüsoy M., Ertan R.

MEDICINAL CHEMISTRY RESEARCH, cilt.18, sa.1, ss.1-7, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 1
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1007/s00044-007-9081-0
  • Dergi Adı: MEDICINAL CHEMISTRY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1-7
  • Anahtar Kelimeler: Thiazolidine-2,4-diones, Thiazole derivatives, Antioxidant activities, ANTIOXIDANT, THIAZOLIDINEDIONES, THIAZOLE, FOOD
  • Ankara Üniversitesi Adresli: Evet

Özet

In this study, a series of 2,4-dichlorothiazolyl thiazolidine-2,4-dione (Ia-f) and 4-chloro-2-benzylsulfanylthiazolyl-thiazolidine-2,4-dione derivatives (IIa-f) were tested for their antioxidant properties by determining their effects on superoxide anion formation, and the 2,2-diphenyl-1-picrylhydrazyl (DPPH) stable free radical. Compound Ic showed the best superoxide anion scavenging activity at the 10(-3) M and 10(-4) M concentrations. The compounds (Ia-f and IIa-f) had the strong DPPH radical scavenger capacity at the 10(-3) M concentration. Compound Ib, Id, and Ie showed similar activity to butylated hydroxytoluene (BHT) at 10(-3) M and 10(-4) M concentrations.