Radical scavenging capacities of some thiazolylthiazolidine-2,4-dione derivatives
MEDICINAL CHEMISTRY RESEARCH, cilt.18, sa.1, ss.1-7, 2009 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 18 Sayı: 1
- Basım Tarihi: 2009
- Doi Numarası: 10.1007/s00044-007-9081-0
- Dergi Adı: MEDICINAL CHEMISTRY RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1-7
- Anahtar Kelimeler: Thiazolidine-2,4-diones, Thiazole derivatives, Antioxidant activities, ANTIOXIDANT, THIAZOLIDINEDIONES, THIAZOLE, FOOD
- Ankara Üniversitesi Adresli: Evet
Özet
In this study, a series of 2,4-dichlorothiazolyl thiazolidine-2,4-dione (Ia-f) and 4-chloro-2-benzylsulfanylthiazolyl-thiazolidine-2,4-dione derivatives (IIa-f) were tested for their antioxidant properties by determining their effects on superoxide anion formation, and the 2,2-diphenyl-1-picrylhydrazyl (DPPH) stable free radical. Compound Ic showed the best superoxide anion scavenging activity at the 10(-3) M and 10(-4) M concentrations. The compounds (Ia-f and IIa-f) had the strong DPPH radical scavenger capacity at the 10(-3) M concentration. Compound Ib, Id, and Ie showed similar activity to butylated hydroxytoluene (BHT) at 10(-3) M and 10(-4) M concentrations.