The relationship between coronary collateral artery development and inflammatory markers

Oguz D., ATMACA Y., ÖZDÖL Ç., Ozdemir A., TULUNAY KAYA C., EROL Ç.

ANATOLIAN JOURNAL OF CARDIOLOGY, sa.4, ss.336-341, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2014
  • Doi Numarası: 10.5152/akd.2014.4612
  • Dergi Adı: ANATOLIAN JOURNAL OF CARDIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.336-341
  • Anahtar Kelimeler: collateral arteries, inflammatory markers, stable angina pectoris, angiogenesis, regression analysis, C-REACTIVE PROTEIN, MYOCARDIAL-INFARCTION, ALPHA, MYELOPEROXIDASE, ARTERIOGENESIS, CIRCULATION, DISEASE, COUNT
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective: This study aims to show the effect of myeloperoxidase (MPO), hsCRP, TNF-alpha values and leukocyte count on the development of coronary collateral arteries in patients with severely diseased coronary arteries. Methods: Current study is an observational cross-sectional study. In the study, 295 patients who had functional obstruction or total coronary occlusion at least 1 month on their angiograms were included. We divided the study population into two groups according to their collateral grade as good collateral (Group 1) (169 patients) and poor collateral (Group 2) (126 patients). Multiple logistic regression analysis was used for independent variables associated with the coronary collateral grade. Results: History of stable angina pectoris was statistically more prevalent in good collateral group (61.5% and 48.4%, p=0.025). Furthermore, MPO activation was higher in good collateral group and the difference was statistically significant (3.7 U/mL and 3.0 U/mL p=0.001). In multiple logistic regression analysis, stable angina pectoris [OR 1.7, 95% CI (1.05-2.8), p=0.03] and high MPO levels [OR 2.7, 95% CI (1.7-4.3), p<0.001] were found to be independent predictors of good collateral development. Conclusion: We think that proinflammatory enzymes and cytokines released from these cells rather than inflammatory cells themselves may play an important role on the collateral development.