Akademik Veri Yönetim Sistemi
Composite Structures, cilt.389, 2026 (SCI-Expanded, Scopus)
Composite scaffolds generally serve only as a passive environment for cells and lack the natural bioactivity found in bone grafts. To enhance bioactivity, ion-substituted hydroxyapatite (HAp) particles in which calcium or phosphate ions are substituted with bioactive ions represent a promising strategy. Among these bioactive ions, strontium is well-known for its osteogenic properties, while boron has been reported to induce angiogenesis. In this study, a novel composite scaffold composed of methacrylated κ-carrageenan (κ-Car-MA) and boron/strontium co-substituted HAp (B-Sr-HAp) was developed to improve the bioactivity and load-bearing capacity of the κ-Car-MA-based structure. The release profiles of boron and strontium ions were monitored in vitro over 21 days and found that boron and strontium concentrations were 35.82 ± 0.62 mg/L and 155.15 ± 8.19 mg/L, respectively. Mechanical compression tests demonstrated that the κ-Car-MA-B-Sr-HAp composite exhibited improved mechanical properties, increasing its compressive strength (from 80.52 ± 11.21 kPa to 123.19 ± 12.48 kPa) and compressive modulus (from 4.34 ± 1.76 kPa to 8.50 ± 3.75 kPa) compared to the κ-Car-MA control group, while maintaining cyto- and hemo-compatibility. Additionally, a preliminary chick chorioallantoic membrane (CAM) assay revealed that the κ-Car-MA-B-Sr-HAp composite possesses pro-angiogenic performance indicating its potential to be used as a bioactive bone graft material in hard tissue applications.