The effect of hippomarathrum microcarpum petrov (apiaceae) growing in Turkey on PC3 cancer cell proliferation

KARAKAYA S., BAKAR ATEŞ F., KILIÇ C. S.

Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.40, sa.2, ss.19-25, 2016 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 2
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1501/eczfak-0000000581
  • Dergi Adı: Ankara Universitesi Eczacilik Fakultesi Dergisi
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.19-25
  • Anahtar Kelimeler: Antiproliferative, Apiaceae, Cancer, Hippomarathrum microcarpum, Prostate
  • Ankara Üniversitesi Adresli: Evet

Özet

© 2016 University of Ankara. All rights reserved.Apiaceae is the 3rd largest family of Turkey with the largest genus, which is widely distributed throughout the world and represented in our country with 109 genera and 450 species. The genus Hippomarathrum has 28 species which are outspread in the North, Northwest, West and Central of Iran, Turkey, Caucasus and Iraq and one of this species H. microcarpum Petrov is a plant which grows wild in Turkey and is used as food by the people in Eastern Anatolia. In this study, the in vitro anticancer activity of the aqueous and ethanol extracts obtained from H. microcarpum was investigated on cancer cell proliferation. For this purpose human prostate (PC-3) cells were used and measurements were performed via MTT test. Aqueous and ethanol extracts obtained from aerial parts exhibited potent inhibitor effects on cell proliferation. Ethanol extract inhibited the proliferation of PC-3 cell at 24th hour with a 12.99 mg/mL IC50 value.