AA amyloidosis associated with systemic lupus erythematosus: impact on clinical course and outcome

Yilmaz B. A., Duzgun N., Mete T., YAZICIOĞLU L., Sayki M., ENSARİ A., ...Daha Fazla

RHEUMATOLOGY INTERNATIONAL, cilt.28, sa.4, ss.367-370, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 4
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1007/s00296-007-0431-5
  • Dergi Adı: RHEUMATOLOGY INTERNATIONAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.367-370
  • Anahtar Kelimeler: amyloidosis, cardiovascular disease, nephrotic syndrome, sepsis, systemic lupus erythematosus, PULMONARY AMYLOIDOSIS, RENAL AMYLOIDOSIS, INVOLVEMENT
  • Ankara Üniversitesi Adresli: Evet

Özet

Secondary amyloidosis (AA amyloidosis) has rarely been described in patients with systemic lupus erythematosus (SLE). We, herein, present a 56-year-old female patient, who developed AA amyloidosis following a 22-year history of SLE. She developed severe mitral regurgitation complicated with chordae tendinea rupture that led to acute congestive heart failure and went on a mitral valve replacement, where no flare symptoms of SLE were present. Three months after the operation, she presented with a nephrotic-range proteinuria, acute renal failure, and severe sepsis. She was found to have new vegetations on replaced valve and multi-organ failure caused her death. Re-evaluation of the excised mitral valve revealed AA amyloid deposition. Post-mortem biopsies from the kidney and bone marrow also revealed secondary amyloidosis.