Short-term effects of arsenic sulfur in deficits of contractile and relaxant responses on urinary bladder: Pharmacological and structural changes

GÜR S., Dogan A., Dogan M., KARAHAN S. T., Can B., Hafez G., ...Daha Fazla

Urologia Internationalis, cilt.74, sa.3, ss.272-275, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 74 Sayı: 3
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1159/000083562
  • Dergi Adı: Urologia Internationalis
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.272-275
  • Anahtar Kelimeler: arsenic sulfur, adenosine triphosphate, carbachol, electrical field stimulation, isoproterenol, urinary bladder, DIMETHYLARSINIC ACID, INHIBITION
  • Ankara Üniversitesi Adresli: Evet

Özet

Introduction: Our goal was to investigate the effects of arsenic sulfur (AsS) on the detrusor smooth muscle reactivity. Material and Methods: AsS (100 ppm μg/g) in drinking water was administered for 2 weeks to two groups of female Wistar rats. The contractile responses of urinary bladders to electrical field stimulation, carbachol, ATP and KCl, and the relaxant responses to ATP, adenosine and isoproterenol were examined. Urinary bladder strips were collected for light microscopic examination. Results: Our results demonstrate that oral inorganic AsS exposure induced enhanced contractile and reduced relaxant responses in rats. We hypothesize that AsS is involved in deficiencies of isolated urinary bladder in rats. Conclusion: These functional and morphological changes may be important as an intermediate link in urinary bladder oncogenesis induced by AsS. Copyright © 2005 S. Karger AG.