High CD95 expression of BAL lymphocytes predicts chronic course in patients with sarcoidosis

Ozdemir Ö., ÇELİK G., Dalva K., Ulger F., ELHAN A. H., BEKSAÇ M.

RESPIROLOGY, cilt.12, sa.6, ss.869-873, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 6
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1111/j.1440-1843.2007.01151.x
  • Dergi Adı: RESPIROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.869-873
  • Anahtar Kelimeler: CD45RO, CD95, prognosis, sarcoidosis, BRONCHOALVEOLAR LAVAGE FLUID, T-CELL SUBSETS, PULMONARY SARCOIDOSIS, FAS CD95, APOPTOSIS, DISEASE, PROGNOSIS
  • Ankara Üniversitesi Adresli: Evet

Özet

Background and objective: The prognosis of sarcoidosis is highly variable, with spontaneous remission in some patients. Apoptosis may be associated with spontaneous resolution of the granulomata. CD95 (Fas), an apoptotic molecule, and CD29 and CD45RO (T-cell memory markers) are expressed at higher levels on T lymphocytes from sarcoid patients compared with normal subjects. However, the prognostic significance of CD95, CD29 and CD45RO expression in sarcoidosis is not clear. It was hypothesized that expression of CD95 would correlate with spontaneous remission.