Association of cytokine gene polymorphisms in CWP and its severity in Turkish coal workers

Ates İ., SÜZEN H. S., Yucesoy B., TEKİN İ. Ö., Karakaya A.

AMERICAN JOURNAL OF INDUSTRIAL MEDICINE, cilt.51, sa.10, ss.741-747, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 10
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1002/ajim.20632
  • Dergi Adı: AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.741-747
  • Anahtar Kelimeler: occupational exposure, coal workers' pneumoconiosis, Turkish coal workers, cytokines, cytokine gene polymorphisms, TUMOR-NECROSIS-FACTOR, FACTOR-ALPHA GENE, INTERLEUKIN-1 RECEPTOR ANTAGONIST, TRANSFORMING GROWTH-FACTOR-BETA-1, PROMOTER POLYMORPHISM, IL-6 GENE, TNF-ALPHA, SILICOSIS, DISEASE, PNEUMOCONIOSIS
  • Ankara Üniversitesi Adresli: Evet

Özet

Background Cytokines appear to play a key role in some inflammatory reactions affecting the interactions among pro- and anti-inflammatory mechanisms that result in several diseases such as coal workers' pneumoconiosis (CWP). In this study, to determine the cytokine gene profiles of Turkish coal miners, we performed genotyping analysis to investigate the polymorphisms of CWP-related pro-inflanunatory (TNFA, IL1A, IL1B, and IL6) and anti- inflammatory cytokines (IL-1RN and TGFB1). An additional goal was to observe whether these cytokine gene polymorphisms influence the development risk and severity of.