The Determination of Timolol Maleate Using Silver/Tannic Acid/Titanium Oxide Nanocomposite as an Electrochemical Sensor in Real Samples

Mehmandoust M., ÇAKAR S., ÖZACAR M., ERK N.

ELECTROANALYSIS, cilt.34, sa.7, ss.1150-1162, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 7
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1002/elan.202100363
  • Dergi Adı: ELECTROANALYSIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Applied Science & Technology Source, BIOSIS, Chimica, Communication Abstracts, Metadex, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.1150-1162
  • Anahtar Kelimeler: Beta-blocker medication, Timolol maleate, Electrochemical sensor, Chronoamperometry, real samples, CARBON-PASTE ELECTRODE, DORZOLAMIDE HYDROCHLORIDE, HPLC METHOD, ACID, NANOPARTICLES, GLAUCOMA, DRUG
  • Ankara Üniversitesi Adresli: Evet

Özet

Herein, a portable and cost-effective electrochemical sbased on Silver/tannic acid/titanium dioxide/glassy carbon electrode (Ag/TA@ TiO2/GCE) was fabricated to determine timolol(TM) assay. The Ag/TA@TiO2/GCE offered an irreversible oxidation peak at +0.99 V, and exhibited an extraordinary electrochemical performance with a wide linear working ranges from 0.01-0.84 and 0.84-49.0 mu M and a low detection limit of 5.2 nM. The detection of TM in the presence of interfering agents and real samples was also analyzed. The sensor's selectivity was studied by comparing the binding of TM, propranolol, nebivolol, and metoprolol. The developed electrochemical sensing platform could have promising potential for the determination of TM in clinical samples.