Restoration of Antibiotic Effectiveness with P. hartigii Extract Against Multidrug-Resistant E. coli

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Altınöz E., Akata I., Altuner E. M.

The 4th International Electronic Conference on Antibiotics, Basel, İsviçre, 21 - 23 Mayıs 2025, cilt.35, sa.1, ss.1-7, (Tam Metin Bildiri)

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Cilt numarası: 35
  • Basıldığı Şehir: Basel
  • Basıldığı Ülke: İsviçre
  • Sayfa Sayıları: ss.1-7
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Ankara Üniversitesi Adresli: Evet

Özet

Antibiotic resistance poses a critical threat to global health, largely driven by bacterial efflux pumps that expel antibiotics and reduce their efficacy. This study investigated the potential of Phellinus hartigii ethyl acetate extract (Ph-Ace) to inhibit efflux pumps and restore antibiotic activity against multidrug-resistant Escherichia coli strains. In vitro assays demonstrated that Ph-Ace effectively inhibited efflux pumps, enhancing the efficacy of resistant antibiotics. GC/MS analysis identified key components such as nonadecane and octacosane. These findings suggest Ph-Ace as a promising natural efflux pump inhibitor. Further molecular and clinical studies are required to confirm its therapeutic potential.