Akademik Veri Yönetim Sistemi
Nanomaterials, cilt.15, sa.22, 2025 (SCI-Expanded, Scopus)
Background/Objectives: This study was conducted to investigate the morphological impact of carbamazepine (CBZ) coated with carbon nanodots functionalised with silver nanoparticles (CNDs@AgNPs) and metal–organic framework (MOF-5) nanoparticles on the hearts of male rats with experimental epilepsy. Methods: Seventy male Wistar rats were randomly selected for the study and divided into ten groups of seven animals each. Haematoxylin–eosin staining was performed on heart tissue, and the levels of interleu-kin-6 (IL-6) and catalase (CAT) and the oxidative stress index (OSI) were determined bio-chemically. In addition, we performed morphological measurements of the heart. Results: When the heart tissues were evaluated histopathologically in all groups, it was observed that cells with pyknotic nuclei and haemorrhagic areas increased in the heart images, especially in the PTZ group with epilepsy only. Histologically normal cardiac cells and cardiac tissue were observed in the other groups. The distance between the atria was below 10 mm only in PTZ + CBZ 50 mg/kg and PTZ + CNDs@MOF-5 25 mg/kg groups. The distance between the apex of the heart and the base of the heart was the lowest in CNDs@MOF-5 25 mg/kg and CNDs@MOF-5 50 mg/kg groups. Conclusions: PTZ-induced epilepsy causes significant histopathological changes, while cardiac tissue structure is largely preserved in the treatment groups. In our literature review, we did not find any previous studies examining the effects of carbamazepine coated with two different types of nanoparticles on the cardiac morphology in an experimental epilepsy model.