Construction of a simple and selective electrochemical sensor based on Nafion/TiO2 for the voltammetric determination of olopatadine

Mehmandoust M., Mehmandoust A., ERK N.

JOURNAL OF ELECTROCHEMICAL SCIENCE AND ENGINEERING, cilt.12, sa.1, ss.91-103, 2021 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 1
  • Basım Tarihi: 2021
  • Doi Numarası: 10.5599/jese.1117
  • Dergi Adı: JOURNAL OF ELECTROCHEMICAL SCIENCE AND ENGINEERING
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.91-103
  • Anahtar Kelimeler: Monitoring, screen-printed electrode, differential pulse voltammetry, PASTE ELECTRODE, TIO2, PENICILLAMINE, NANOPARTICLES
  • Ankara Üniversitesi Adresli: Evet

Özet

A selective and facile voltammetric method based on titanium dioxide nanoparticles and Nafion (Nafion/TiO2 NPs) on the screen-printed electrode (SPE) was proposed for olopatadine determination. Followed by the synthesis of TiO2 nanoparticles, various methods, including high-resolution transmission electron microscopy (HR-TEM), ultraviolet-visible spectroscopy (UV-Vis), energy-dispersive X-ray (EDX) Raman spectrum, and electrochemical impedance spectroscopy (EIS) were utilized to characterize the nanomaterials. Nafion/TiO2 on the screen-printed electrode (NFN/TiO2/SPE) was used to determine olopatadine in concentration ranges of 0.01 to 0.07 and 0.07 to 14.6 mu M with a limit of quantification as low as 7.0 nM, via differential pulse voltammetry technique. The NFN/TiO2/SPE offered a high-performance ability to determine olopatadine in the eye drop sample with satisfactory recovery data of 98.2-99.0 %. Also, the developed electrode showed good reproducibility, repeatability, and high selectivity features. The obtained results indicate that NFN/TiO2/SPE could be utilized as an appropriate candidate for electrochemical olopatadine sensing.