Penetration of topically applied tacrolimus into the aqueous humor in Behcet's disease

Yalcindag F. N., ŞERMET F., Ozdemir O.

ANNALS OF OPHTHALMOLOGY, cilt.39, sa.1, ss.15-17, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 1
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1007/bf02697321
  • Dergi Adı: ANNALS OF OPHTHALMOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.15-17
  • Ankara Üniversitesi Adresli: Evet

Özet

We investigated the concentration of tacrolimus in aqueous humor, and serum of patients with ocular Behcet's disease after topical application in 11 patients. All received 1 drop of isotonic tacrolimus solution 0.3% every 6 hours for 3 days. The mean tacrolimus concentration in the aqueous and serum, as measured by microparticle enzyme immunoassay, were 12.49 and 0.76 ng/mL, respectively. Tacrolimus may be a promising treatment modality in anterior uveitis in Behcet's disease by topical application.