Influence of rifampin on capsule formation around silicone implants in a rat model

Unlu R. E., Yilmaz A. D., Orbay H., Can B., Tekdemir İ., Sensoz O.

Aesthetic Plastic Surgery, cilt.31, sa.4, ss.358-364, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 4
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1007/s00266-006-0248-8
  • Dergi Adı: Aesthetic Plastic Surgery
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.358-364
  • Anahtar Kelimeler: peri-implant capsule formation, rifampin, silicone implants, stapylococcus epidermidis, BREAST IMPLANTS, MAMMARY IMPLANTS, AUGMENTATION MAMMAPLASTY, INTRALUMINAL ANTIBIOTICS, CONSTRICTIVE FIBROSIS, SMOOTH IMPLANTS, CONTRACTURE, PROSTHESES, EXPERIENCE, INFECTION
  • Ankara Üniversitesi Adresli: Evet

Özet

This study investigated the effect of rifampin on the thickness of capsules around silicone implants by bactericidal activity against Stapylococcus epidermidis. Silicone blocks (1 x 1 cm) were placed into pockets created for each of the 40 rats included in the study. In group 1, the operation was performed under aseptic conditions. In group 2, standard S. epidermidis was inoculated into the pocket, whereas rifampin and S. epidermidis were applied in group 3. In group 4, only rifampin was applied topically on implants. After 12 weeks, the peri-implant capsules were removed and examined under a photomicroscope and a scanning electron microscope. The mean thickness of the capsules was 63.307 μm in group 1, 111.538 μm in group 2, 43.076 μm in group 3, and 30.384 μm in group 4. The differences between groups 2 and 3 and groups 2 and 4 were found to be statistically significant (p < 0.001). Rifampin appears to be an agent for preventing peri-implant capsule formation. © 2007 Springer Science+Business Media, LLC.