DIFFERENTIAL PULSE VOLTAMMETRIC DETERMINATION OF ROSUVASTATIN VIA GLASSY CARBON ELECTRODE

KARADURMUŞ L., KURBANOĞLU S., USLU B., ÖZKAN S. A.

REVUE ROUMAINE DE CHIMIE, cilt.62, sa.6-7, ss.579-586, 2017 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 62 Sayı: 6-7
  • Basım Tarihi: 2017
  • Dergi Adı: REVUE ROUMAINE DE CHIMIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.579-586
  • Anahtar Kelimeler: electrochemistry, voltammetry, rosuvastatin, glassy carbon electrode, BIOLOGICAL-FLUIDS, SQUARE-WAVE, NANOTUBES, CALCIUM, PHARMACOLOGY, HPLC, ELECTROCHEMISTRY, PHARMACOKINETICS, STATINS, PLASMA
  • Ankara Üniversitesi Adresli: Evet

Özet

In this work, the electrochemical behavior of Rosuvastatin which is a member of the drug class of statins used to treat high cholesterol and related conditions, and to prevent cardiovascular disease, was investigated with in a wide pH range (pH 0.3-7.0) using differential pulse voltammetric technique at glassy carbon electrode. All the parameters effecting the differential pulse, were optimized, and with differential pulse voltammetric techniques, the maximum peak current was observed in the 0.1 M sulfuric acid medium. Scan rate studies were also conducted using cyclic voltammetric technique, in the 0.1 M sulfuric acid medium, and the electrochemical reaction of rosuvastatin was found as diffusion-controlled mechanism. Linear relation range specified in the range of 0.005-0.1 mM and limit of detection calculated as 1.33 nM. In optimized conditions, the proposed method was applied for the determination of rosuvastatin from pharmaceutical dosage forms named, ROSUCOR (R) and REAKT (R).