Red blood cell indexes in patients with hereditary spherocytosis and beta-thalassemia combination

Akar N., Gokce H.

PEDIATRIC HEMATOLOGY AND ONCOLOGY, vol.19, no.8, pp.569-573, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 8
  • Publication Date: 2002
  • Doi Number: 10.1080/08880010290097431
  • Journal Name: PEDIATRIC HEMATOLOGY AND ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.569-573
  • Keywords: red blood cell, spherocytosis, thalassemia, ERYTHROCYTE INDEXES, DEFICIENCY
  • Ankara University Affiliated: No

Abstract

The spontaneous occurrence of hereditary spherocytosis (HS) and beta-thalassemia in the same patient is a rare event. The mean corpuscular hemoglobin concentration is elevated above the reference range in ha ( to two-thirds of patients with HS, but there are no data for the HS/beta-thal combinations for the red blood cell indexes. This study reassessed these values in these particular patients. Hemoglobin, hematociit, mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), red cell distribution (RDW), and reticulocyte count were documented from 43 HS patients, 13 of which were from 10 families with the combination of beta-thal and HS; 28 controls were also included. Patients with HS/beta-thal have a significantly lower MCV, mean corpuscular hemoglobin, and MCHC and a significantly higher RDW than normal control subjects; 95% of beta-thalassemia carriers are free of clinical symptoms. When red blood cell indexes reveal a possibility of a beta-thalassemia carrier state with the symptoms of hemolytic anemia, HS should be considered.