Preparation and evaluation of poly(lactic-co-glycolic acid) microparticles as a carrier for pulmonary delivery of recombinant human interleukin-2: II. In vitro studies on aerodynamic properties of dry powder inhaler formulations

DEVRİM GÖKBERK B., BOZKIR A., Canefe K.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, cilt.37, sa.11, ss.1376-1386, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 11
  • Basım Tarihi: 2011
  • Doi Numarası: 10.3109/03639045.2011.576680
  • Dergi Adı: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1376-1386
  • Anahtar Kelimeler: Dry powder inhalation, pulmonary drug delivery, coarse carrier, mannitol, interleukin-2, PLGA microparticles, SALBUTAMOL SULFATE, POTENTIAL CARRIERS, CYSTIC-FIBROSIS, LUNG-CANCER, INHALATION, PARTICLES, THERAPY, RELEASE, INSULIN, MICROSPHERES
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective: The aim of this study was the preparation and evaluation of dry powder formulations of recombinant human interleukin-2 (rhIL-2)-loaded microparticles to be administered to the lung by inhalation.