Preparation and evaluation of poly(lactic-co-glycolic acid) microparticles as a carrier for pulmonary delivery of recombinant human interleukin-2: II. In vitro studies on aerodynamic properties of dry powder inhaler formulations

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DEVRİM GÖKBERK B., BOZKIR A., Canefe K.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, cilt.37, sa.11, ss.1376-1386, 2011 (SCI-Expanded, Scopus)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 37 Sayı: 11
• Basım Tarihi: 2011
• Doi Numarası: 10.3109/03639045.2011.576680
• Dergi Adı: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.1376-1386
• Anahtar Kelimeler: Dry powder inhalation, pulmonary drug delivery, coarse carrier, mannitol, interleukin-2, PLGA microparticles, SALBUTAMOL SULFATE, POTENTIAL CARRIERS, CYSTIC-FIBROSIS, LUNG-CANCER, INHALATION, PARTICLES, THERAPY, RELEASE, INSULIN, MICROSPHERES
• Ankara Üniversitesi Adresli: Evet

Özet

Objective: The aim of this study was the preparation and evaluation of dry powder formulations of recombinant human interleukin-2 (rhIL-2)-loaded microparticles to be administered to the lung by inhalation.