A new generation electrochemical sensor based on Graphene nanosheets/Gold nanoparticles/Nafion nanocomposite for determination of Silodosin

ER E., ÇELİKKAN H., ERK N., Aksu M. L.

ELECTROCHIMICA ACTA, cilt.157, ss.252-257, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 157
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.electacta.2015.01.020
  • Dergi Adı: ELECTROCHIMICA ACTA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.252-257
  • Anahtar Kelimeler: Electrochemical sensor, Graphene, Chemical modified electrode, Gold nanoparticle, Silodosin, ASCORBIC-ACID, OXIDE, GOLD, COMPOSITES, REDUCTION, DOPAMINE
  • Ankara Üniversitesi Adresli: Evet

Özet

It is the first time that a rapid, facile, highly sensitive and selective electrochemical sensor based on graphene nanosheets/gold nanoparticles/nafion nanocomposite modified electrode (GRP/AuNPs/NFN) was developed for the electro-oxidation and quantification of silodosin (SLD). The chemical formation of GRP/AuNPs nanocomposite was verified by x-ray diffraction (XRD), fourier transform infrared spectroscopy (FT-IR) and transmission electron spectroscopy (TEM). The electrochemical oxidation of SLD has been investigated at GRP/AuNPs/NFN by the use of adsorptive stripping differential pulse voltammetry (AdSDPV). The developed electrode exhibited excellent electrochemical activity towards the electrochemical oxidation of SLD. Under optimal conditions, GRP/AuNPs/NFN demonstrated a wide linearity ranging from 10-330 nM with a detection limit of 3.8 nM (S/N = 3). Therefore, the electrode developed can conveniently be used for the electroanalytical determination of SLD in pharmaceutical or biological samples. (C) 2015 Elsevier Ltd. All rights reserved.