Thrombospondin-1, vascular endothelial growth factor expression and microvessel density in renal cell carcinoma and their relationship with multifocality

Baltaci S., Orhan D., Gogus Ç. M., Filiz E., Tulunay O., Gogus O.

EUROPEAN UROLOGY, vol.44, no.1, pp.76-81, 2003 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 1
  • Publication Date: 2003
  • Doi Number: 10.1016/s0302-2838(03)00192-1
  • Journal Name: EUROPEAN UROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.76-81
  • Keywords: renal cell carcinoma, multifocality, thrombospondin-1, vascular endothelial growth factor, CLINICAL-SIGNIFICANCE, TUMOR ANGIOGENESIS, CANCER, PROGRESSION, METASTASIS, STAGE, LUNG
  • Ankara University Affiliated: Yes

Abstract

Objective: To evaluate the relevance of microvessel density (MVD) and the angiogenic factors, vascular endothelial growth factor (VEGF, an important angiogenic factor in solid tumors) and thrombospondin-1 (TSP-1, a potent inhibitor of angiogenesis), to multifocality of renal cell carcinoma (RCC).