The breakdown of preformed advanced glycation end products reverses erectile dysfunction in streptozotocin-induced diabetic rats: Preventive versus curative treatment

Usta M., Kendirci M., GÜR S., Foxwell N., Bivalacqua T., Cellek S., ...Daha Fazla

JOURNAL OF SEXUAL MEDICINE, cilt.3, sa.2, ss.242-250, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 3 Sayı: 2
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1111/j.1743-6109.2006.00217.x
  • Dergi Adı: JOURNAL OF SEXUAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.242-250
  • Anahtar Kelimeler: advanced glycation end products, diabetes, nitric oxide, nitrergic, erectile dysfunction, ALT-711, diabetic complications, cross-link breaker, NITRIC-OXIDE SYNTHASE, NITRERGIC NEUROPATHY, SMOOTH-MUSCLE, PENIS, AMINOGUANIDINE, RELAXATION, IMPOTENCE, BREAKERS
  • Ankara Üniversitesi Adresli: Evet

Özet

Objectives. Accumulation of advanced glycation end products (AGEs) has been linked to many of the complications of diabetes mellitus, including erectile dysfunction (ED). Furthermore, it has been demonstrated that inhibitors of AGE formation, such as aminoguanidine, can prevent ED in diabetic animals. However, it is unknown whether late administration of a putative cross-link breaker, ALT-711, can reverse diabetic ED. We therefore compared ALT 711 and aminoguanidine in their ability to reverse ED in diabetic rats.