Synthesis, characterization, cytotoxicity, and DNA binding of some new platinum(II) and platinum(IV) complexes with benzimidazole ligands
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.25, sa.4, ss.502-508, 2010 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 25 Sayı: 4
- Basım Tarihi: 2010
- Doi Numarası: 10.3109/14756360903282858
- Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.502-508
- Anahtar Kelimeler: Benzimidazole, cytotoxic activity, DNA binding, gel electrophoresis, platinum complexes, ANTITUMOR-ACTIVITY, RESISTANCE, ACID, MECHANISMS, REDUCTION, SPECTRA, MCF-7
- Ankara Üniversitesi Adresli: Evet
Özet
In this study, two Pt(II) and three Pt(IV) complexes with the structures of [PtL2 Cl-2] (1), [PtL2 I-2] (2), [PtL2 Cl-2 (OH)(2)] (3), [PtL2Cl2 (OCOCH3)(2)] (4), and [PtL2Cl4] (5) (L = benzimidazole as carrier ligand) were synthesized and evaluated for their in vitro antiproliferative activities against the human MCF-7, HeLa, and HEp-2 cancer cell lines. The influence of compounds 1-5 on the tertiary structure of DNA was determined by their ability to modify the electrophoretic mobility of the form I and II bands of pBR322 plasmid DNA. The inhibition of BamH1 restriction enzyme activity of compounds 1-5 was also determined. In general, it was found that compounds 1-5 were less active than cisplatin and carboplatin against MCF-7 and HeLa cell lines (except for 1, which was found to be more active than carboplatin against the MCF-7 cell line). Compounds 1 and 3 were found to be significantly more active than cisplatin and carboplatin against the HEp-2 cell line.