Synthesis, characterization, cytotoxicity, and DNA binding of some new platinum(II) and platinum(IV) complexes with benzimidazole ligands

UTKU S., Gumus F., TEZCAN ÜLGER S., SERİN M. S., ÖZKUL A.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.25, sa.4, ss.502-508, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 4
  • Basım Tarihi: 2010
  • Doi Numarası: 10.3109/14756360903282858
  • Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.502-508
  • Anahtar Kelimeler: Benzimidazole, cytotoxic activity, DNA binding, gel electrophoresis, platinum complexes, ANTITUMOR-ACTIVITY, RESISTANCE, ACID, MECHANISMS, REDUCTION, SPECTRA, MCF-7
  • Ankara Üniversitesi Adresli: Evet

Özet

In this study, two Pt(II) and three Pt(IV) complexes with the structures of [PtL2 Cl-2] (1), [PtL2 I-2] (2), [PtL2 Cl-2 (OH)(2)] (3), [PtL2Cl2 (OCOCH3)(2)] (4), and [PtL2Cl4] (5) (L = benzimidazole as carrier ligand) were synthesized and evaluated for their in vitro antiproliferative activities against the human MCF-7, HeLa, and HEp-2 cancer cell lines. The influence of compounds 1-5 on the tertiary structure of DNA was determined by their ability to modify the electrophoretic mobility of the form I and II bands of pBR322 plasmid DNA. The inhibition of BamH1 restriction enzyme activity of compounds 1-5 was also determined. In general, it was found that compounds 1-5 were less active than cisplatin and carboplatin against MCF-7 and HeLa cell lines (except for 1, which was found to be more active than carboplatin against the MCF-7 cell line). Compounds 1 and 3 were found to be significantly more active than cisplatin and carboplatin against the HEp-2 cell line.