Cell fate regulation during preimplantation development: A view of adhesion-linked molecular interactions


Sozen B., CAN A., DEMİR N.

DEVELOPMENTAL BIOLOGY, cilt.395, sa.1, ss.73-83, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 395 Sayı: 1
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.ydbio.2014.08.028
  • Dergi Adı: DEVELOPMENTAL BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.73-83
  • Anahtar Kelimeler: Early embryogenesis, Junctions, Cell-cell interactions, Cell polarity, Compaction, Lineage specification, EARLY MOUSE EMBRYO, TIGHT-JUNCTION BIOGENESIS, GENE-EXPRESSION, PRIMITIVE ENDODERM, HIPPO PATHWAY, 4-CELL STAGE, STEM-CELLS, E-CADHERIN, IN-VITRO, BLASTOCYST FORMATION
  • Ankara Üniversitesi Adresli: Evet

Özet

In the developmental process of the early mammalian embryo, it is crucial to understand how the identical cells in the early embryo later develop different fates. Along with existing models, many recently discovered molecular, cellular and developmental factors play roles in cell position, cell polarity and transcriptional networks in cell fate regulation during preimplantation. A structuring process known as compaction provides the "start signal" for cells to differentiate and orchestrates the developmental cascade. The proper intercellular junctional complexes assembled between blastomeres act as a conducting mechanism governing cellular diversification. Here, we provide an overview of the diversification process during preimplantation development as it relates to intercellular junctional complexes. We also evaluate transcriptional differences between embryonic lineages according to cell- cell adhesion and the contributions of adhesion to lineage commitment. These series of processes indicate that proper cell fate specification in the early mammalian embryo depends on junctional interactions and communication, which play essential roles during early morphogenesis. (C) 2014 Elsevier Inc. All rights reserved.