Akademik Veri Yönetim Sistemi
Current Research in Dental Sciences, cilt.32, sa.3, ss.196-200, 2022 (Scopus)
Objective: Periodontal diseases are chronic inflammatory pathologies including in pro-inflammatory cyto-kine-mediated pathogenesis and epigenetic characteristics. We aimed to evaluate pro-inflammatory cytokine [interleukin (IL)-1β, tumour necrosis factor-alpha (TNF-α), and IL-6] gene polymorphisms in patients with periodontal disease. Methods: Patients with periodontitis (n = 25), gingivitis (n = 22), and periodontally healthy controls (n = 18) were enrolled in this study. The periodontal parameters (plaque index, gingival index, probing pocket depth, percent-age of bleding on probing, and clinical attachment level) were recorded, and fasting venous blood samples were obtained. The genotypes and allele frequencies of TNFα-308,-238, IL-1β-511, +3953, IL-6-174,-572 polymor-phisms were performed using polymerase chain reaction–restriction fragment length polymorphism technique. Results: Patients with periodontitis had the highest IL-1β +3953, IL-6-174 ve TNF-α-238 heterozygot geno-types, clinical periodontal parameters and demographic characteristics. IL-1β +3953 [the risk allele 2 (A allele) (GA genotype)] led to an increased risk of periodontitis, IL-6-174 [the risk allele 2 (G/T allele) (CG/CT genotypes)] was associated with gingivitis. Conclusion: Our findings provide important evidence that pro-inflammatory cytokine gene polymorphisms may be involved in the pathogenesis of gingivitis and periodontitis. Control of the cytokine response associated with periodontal diseases may constitute a step towards improving public health by reducing mortality and morbidity rates associated with many infectious-inflammatory diseases.