Green alcoholic solvent and UAE extraction of oleuropein from the Olea europaea L. leaves: Experimental design, optimization, and comparison with Pharmacopoeia method

VURAL N., Cavuldak O. A., KENAR A., AKAY M. A.

SEPARATION SCIENCE AND TECHNOLOGY, cilt.55, sa.10, ss.1813-1828, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 55 Sayı: 10
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1080/01496395.2019.1606014
  • Dergi Adı: SEPARATION SCIENCE AND TECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Agricultural & Environmental Science Database, Analytical Abstracts, Applied Science & Technology Source, Biotechnology Research Abstracts, Chimica, Communication Abstracts, Compendex, INSPEC, Metadex, Pollution Abstracts, DIALNET, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.1813-1828
  • Anahtar Kelimeler: Green alcoholic extraction, UAE, oleuropein, optimization, RSM, ULTRASOUND-ASSISTED EXTRACTION, ANTIOXIDANT ACTIVITY, PHENOLIC-COMPOUNDS, OLIVE LEAVES, LIQUID-EXTRACTION, FLAVONOIDS, MIXTURES, ANTHOCYANINS, TEMPERATURES, SYSTEMS
  • Ankara Üniversitesi Adresli: Evet

Özet

Solvent extraction and UAE were studied for the extraction of the polyphenolic compounds from the olive leaf in MeOH/H2O and EtOH/H2O solvent systems. Box Wilson-CCRD design was used under RSM for the experimental design of alcoholic solvent extraction. Multi-response optimization was solved with the help of pareto areas and optimal input variable values were determined by the desirability function, optimization by fuzzy similar precedable ratio method. It is seen that the developed solvent extraction methods are more advantageous to the European Pharmacopoeia method for especially oleuropein and the other phenolics which have synergetic effect in olive leaf extract.