Microsphere-based once-daily modified release matrix tablets for oral administration in angina pectoris

Sengel-Tuerk C. T., HASÇİÇEK C., Goenuel N.

Journal of Microencapsulation, cilt.25, sa.4, ss.257-266, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 4
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1080/02652040801967228
  • Dergi Adı: Journal of Microencapsulation
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.257-266
  • Anahtar Kelimeler: diltiazem hydrochloride, Compritol (R) 888 ATO, Ludipress (R), Cellactose (R) 80, Eudragit (R) RS 100 microspheres, tablets, DILTIAZEM, MICROPARTICLES, HYDROCHLORIDE, MICROCAPSULES
  • Ankara Üniversitesi Adresli: Evet

Özet

The objective of this research was to develop microsphere-based once-daily modified release tablet formulations of diltiazem hydrochloride (DH), a potent calcium channel blocker used in angina pectoris. For this purpose, DH-loaded microspheres were prepared by the solvent evaporation technique using Eudragit®RS 100. The effect of variation in the drug/polymer ratio on the physical and release characteristics of the microspheres was investigated. After the selection of the suitable microspheres, tablets were compressed using Compritol®888 ATO, Ludipress® and Cellactose®80 as different direct tableting agents and excipients. As a result, modified release tablet formulations of DH-loaded microspheres were designed successfully for oral administration once rather than two or three times a day in angina pectoris.