Akademik Veri Yönetim Sistemi
British Journal of Urology, cilt.80, sa.SUPPL. 2, ss.43, 1997 (SCI-Expanded)
OBJECTIVE:The purpose of this study was to investigate the hypothesis that DMSO enhances the absortation of the intravesical chemotherapeutics. MATERIALS AND METHODS:Fifty female wistar rats received 1.5mg of N-Methyl-N-Nitrosourea (MNU) intravesically every other week (week 0,2,4,6,8) for a total of five doses. After the week 14, evry other week (week 14,16,18,20,22) rats underwent intravesical installation of epirubicin (1mg) or epirubicin+DMSO (50%). The absorbtion of epirubicin was estimated histologically by observing its fluorescence in the bladder. RESULTS:We observed papiller and/or hyperplastic formations in rat bladders (10/50 rat) due to installation of MNU. Epirubicin fluorescence was observed in the entire bladder wall of normal or hyperplastic regions in the rats that were given DMSO prior to epirubicin. Unlike this finding epirubicin was observed only in normal appearing mucosa or in superficial layer of hyperplastic regions. CONCLUSION:Addition of DMSO, to intravesical epirubicin administration enhances the afasorbtion of epirubicin to the entire bladder wail. In that way epirubicin cytotoxicity and antitumor activity can be potansiaiized. This can be useful for both treatment of superficial bladder cancer (especially in local recurrence and progression) and invasive bladder cancer (especially in effective regional chemotherapy).