Akademik Veri Yönetim Sistemi
Klinik Psikofarmakoloji Bulteni, cilt.17, sa.1, ss.9-14, 2007 (SCI-Expanded)
Objective: Antipsychotic medication choose (classical or atypical) and add-on anticholinerjics, add-on depot antipsychotics and need for switching of antipsychotics while medication were examined in schizophrenia and schizoaffective disorder inpatients. Method: In this study, inwhich 787 schizophrenic and schizoaffective inpatients were evaluated retrospectively, we investigated the rate of anticholinergic and depots add on therapies or switching the index medication and compared them among basic features of the patients (i.e. duration of hospitalization, frequence of hospitalization...) Results: Atypical antipsychotis were the treatment of choice in 86.3%. Add on depot antipsychotics rate were %63.8 in group which classical antipsychotic were being used, and %40.2 in atypical group, rate of anticholinergic use were %64.8 in classical group and %50.3 in atypical group, switching the index medication rate were %32.4 in classical group and %19.6 in atypical group, and these results were significant statistically (p<0.05). Furthermore results show that add-on depot antipsychotics rate was higher for quetiapine (51.5%) and clozapine (48.9%) than olanzapine (29.5%) and risperidone (42.9%) treated patients (F=20.5, p<.001). The rate of anticholinergic use was higher in risperidone (67.1%) and quetiapine (52.5%), while olanzapine (37.3%) and clozapine (37.8%) treated patients were being lower (F=50.3, p<.001). Switching the index medication rate was highest for quetiapine (25.3%) and lowest for clozapine (6.7%) treated patients (F=12.63, p<.007). Conclusion: In addition besides results show that atypical antipsychotics were advantageous than classical antipsychotics among add-on depot antipsychotics, rate of anticholinerjics use and switching of index medication, pointed out significant differences among atypical antipsychotics in each also.