Effects of rapamycin treatment on pancreatic fibrosis, cellular apoptosis and oxidative stress in experimental chronic pancreatitis model

Ozturk K., Tasci I., Yasar M., Akay C., Alcigir M., VURAL S., ...Daha Fazla

ACTA GASTRO-ENTEROLOGICA BELGICA, cilt.78, sa.1, ss.3-7, 2015 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 78 Sayı: 1
  • Basım Tarihi: 2015
  • Dergi Adı: ACTA GASTRO-ENTEROLOGICA BELGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.3-7
  • Anahtar Kelimeler: rapamycin, chronic pancreaititis, apoptosis, fibrosis, RAT-LIVER FIBROSIS, STELLATE CELLS, FIBROGENESIS, PROLIFERATION, ACTIVATION, TAURINE, MICE
  • Ankara Üniversitesi Adresli: Evet

Özet

Purpose : Rapamycin reduces hepatic fibrosis by inhibiting hepatic stellate cell activation. The present study investigated whether rapamycin treatment could modify the degree of fibrosis, cellular apoptosis and oxidative stress (OS) in an experimental model of CP.