Synthesis and potent antimicrobial activities of some novel retinoidal monocationic benzimidazoles

ALAGÖZ Z., Alp M., Kus C., Yildiz S., Buyukbingol E., GÖKER A. H.

Archiv der Pharmazie, cilt.339, sa.2, ss.74-80, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 339 Sayı: 2
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1002/ardp.200500168
  • Dergi Adı: Archiv der Pharmazie
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.74-80
  • Anahtar Kelimeler: retinoid skeleton, benzimidazole carboxamidines, antibacterial, antifungal activities, FLUCONAZOLE
  • Ankara Üniversitesi Adresli: Evet

Özet

Several 2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1H- benzimidazole-5-carboxamidine analogues were synthesized for their antibacterial and antifungal activities against S. aureus, Methicillin-resistant S. aureus (MRSA), C. albicans, and C. krusei. MIC values of the targeted compounds 43-58 are comparable to those of Fluconazole and Sultamicillin. The most potent compounds, 51 and 53, showed MIC values as 0.78 and 1.56 μg/mL against S. aureus and C. albicans, respectively. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.