Extracellularly signal-regulated kinase activity in the human endometrium: Possible roles in the pathogenesis of endometriosis

Murk, William; ATABEKOĞLU, CEM; Cakmak, Hakan; HEPER, AYLİN; ENSARİ, ARZU; Kayisli, Umit; Arici, Aydin

doi:10.1210/jc.2007-2051

Extracellularly signal-regulated kinase activity in the human endometrium: Possible roles in the pathogenesis of endometriosis

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Murk W., ATABEKOĞLU C. S., Cakmak H., HEPER A., ENSARİ A., Kayisli U. A., ...More

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol.93, no.9, pp.3532-3540, 2008 (SCI-Expanded)

Publication Type: Article / Article
Volume: 93 Issue: 9
Publication Date: 2008
Doi Number: 10.1210/jc.2007-2051
Journal Name: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.3532-3540
Ankara University Affiliated: Yes

Abstract

Context: Endometriosis is an estrogen-dependent disease characterized by the presence of endometrial tissue outside of the uterine cavity, causing pelvic pain and infertility in 10% of reproductive-aged women. It is unclear why ectopic endometrium remains viable in only a subset of women. ERK1/2 plays key intracellular roles in activating cellular survival and differentiation processes.