Extracellularly signal-regulated kinase activity in the human endometrium: Possible roles in the pathogenesis of endometriosis

Creative Commons License

Murk W., ATABEKOĞLU C. S., Cakmak H., HEPER A., ENSARİ A., Kayisli U. A., ...Daha Fazla

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, cilt.93, sa.9, ss.3532-3540, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 93 Sayı: 9
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1210/jc.2007-2051
  • Dergi Adı: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3532-3540
  • Ankara Üniversitesi Adresli: Evet

Özet

Context: Endometriosis is an estrogen-dependent disease characterized by the presence of endometrial tissue outside of the uterine cavity, causing pelvic pain and infertility in 10% of reproductive-aged women. It is unclear why ectopic endometrium remains viable in only a subset of women. ERK1/2 plays key intracellular roles in activating cellular survival and differentiation processes.