Response of broiler chickens to dietary different yeast cell wall components challenged with Salmonella typhimurium

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SAÇAKLI P., Mickdam E., BAYRAKTAROĞLU A. G., EKİM B., SIZMAZ Ö.

Veterinary Research Communications, cilt.49, sa.6, 2025 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49 Sayı: 6
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1007/s11259-025-10880-z
  • Dergi Adı: Veterinary Research Communications
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Veterinary Science Database
  • Anahtar Kelimeler: Broiler, Prebiotic, Short chain fatty acids, Β-glucan
  • Ankara Üniversitesi Adresli: Evet

Özet

This study assessed the impact of dietary prebiotic supplementation on broiler chickens challenged with Salmonella Typhimurium. In experiment I, the treatments consisted of control (K) [without supplementation]; supplemented with 0.565% autolyzed whole yeast cell (W); supplemented with 0.125% autolyzed whole yeast cell (WP); supplemented with 0.565% enzymatically removed yeast cell wall (CELL) and supplemented with 0.2% pure Mannan-oligosaccharides (MOS) + β-glucan (MB). The second experiment, the Salmonella Typhimurium challenge was performed on day 7 post-hatch. Birds in the CELL group in Experiment I exhibited higher final body weight and weight gain (P = 0.001). On day 21, jejunum villus height (VH) was lower in the MB group, while jejunum crypt depth (CD) was lower in the WP and K groups (P < 0.05). The W group had the lowest VH and CD in the ileum (P < 0.05). At day 35, jejunal villus health was unaffected by prebiotic supplementation, but the CELL group showed the highest VH and CD in the ileum (P < 0.05). Gene expression analysis revealed significant differences in claudin, IL-1β, and IL-10 expressions. In experiment II, the CELL group exhibits the highest final live body weight and weight gain (P < 0.05). Intestinal histology varied among groups and time points. Gene expression analysis indicated upregulation of claudin and occludin in certain groups, while IL-1β was upregulated in all groups and IL-10 showed varied expressions. In conclusion, prebiotic supplementation, particularly yeast cell wall, positively influenced broiler performance, intestinal histology, and gene expression related to the intestinal barrier.