Synthesis and aldose reductase inhibitory effect of ethyl {5-[(2-(4-chloro-benzylsulphanyl)-4-chloro-thi̇azole-5-yl)methylene]-2, 4-dioxo-thi̇azoli̇di̇ne-3-yl} acetate Eti̇l {5-[(2-(4-klorobenzi̇lsulfani̇l)-4-kloroti̇yazol-5- i̇l)meti̇len]-2,4-di̇okso-ti̇yazoli̇di̇n-3-i̇l} asetat bi̇leşi̇ǧi̇ni̇n sentezi̇ ve aldoz redüktaz i̇nhi̇bi̇tör etki̇si̇

BOZDAĞ DÜNDAR O., Daş-Evcimen N.

Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.35, sa.4, ss.245-254, 2006 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 4
  • Basım Tarihi: 2006
  • Dergi Adı: Ankara Universitesi Eczacilik Fakultesi Dergisi
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.245-254
  • Anahtar Kelimeler: Aldose reductase inhibitory effect, Thiazole derivatives, Thiazolidine-2,4-diones
  • Ankara Üniversitesi Adresli: Evet

Özet

In this study, ethyl {5-[(2-(4-chlorobenzylsulphanyl)-4-chlorothiazole-5- yl)methylene]-2,4-dioxo-thiazolidine-3-yl}acetate compound was synthesized and its structure has been elucidated by IR, 1H-NMR, mass spectra and elementary analysis. The synthesized compound was tested for its ability to inhibit rat kidney AR by an in-vitro spectrophotometric assay. Synthesized compound showed inhibitory activity, 6.51±0.97%.