Transcallosal and endoscopic hybrid approach to a rare entity of pediatric intraventricular tumors—cribriform neuroepithelial tumor: a case report and literature review

Mete E. B., Eray H. A., Orhan O., Zaimoglu M., Ersoz C., Dogan İ.

Child's Nervous System, vol.39, no.5, pp.1123-1129, 2023 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 5
  • Publication Date: 2023
  • Doi Number: 10.1007/s00381-023-05897-1
  • Journal Name: Child's Nervous System
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, EMBASE, MEDLINE
  • Page Numbers: pp.1123-1129
  • Keywords: CRINET, Cribriform neuroepithelial tumor, Intraventricular, Third ventricle, GENOMIC ANALYSIS
  • Ankara University Affiliated: Yes


Purpose: Cribriform neuroepithelial tumor (CRINET) is a provisional category of intraventricular tumors, sharing similarities with AT/RTs, and there is a lack of data about its pathology, prognosis, and surgical approaches in the literature. We have been challenged to describe the surgical approach to a rare case of CRINET and describe the intraoperative features since none has been described before. Surgical resection and chemotherapy hold a great importance of favorable prognosis. Methods: Twenty-month-old male with intraventricular tumor underwent transcallosal intraventricular tumor resection and endoscopic intraventricular second look stages. The tumor was initially considered choroid plexus carcinoma and histopathological results pointed CRINET. The patient also received Ommaya reservoir for intrathecal chemotherapy employment. The patient’s preoperative and postoperative MRI scans and tumor’s pathological features are described with a brief history of the disease in the literature. Results: Lack of SMARCB1 gene immunoreactivity and presence of cribriform non-rhabdoid trabecular neuroepithelial cells led to the CRINET diagnosis. The surgical technique helped us to approach directly into the third ventricle and perform total resection and intraventricular lavage. The patient recovered without any perioperative complications and is consulted pediatric oncology for further treatment planning. Conclusion: With our limited knowledge on the matter, our presentation may provide an inside to the course and progress of the CRINET as a very rare tumor and may help to set a basis for future investigations focused on its clinical and pathological features. Long courses of follow-up periods are required for establishing treatment modules and assessing the responses to surgical resection techniques and chemotherapy protocols.