Association of BDNF Val66Met genotype with obesity indicators and metabolic parameters

İnan C. M., Çapraz M., Tekcan A., ÖZÇELİK A. Ö.

International Journal of Food Sciences and Nutrition, cilt.76, sa.8, ss.910-919, 2025 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 76 Sayı: 8
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1080/09637486.2025.2584321
  • Dergi Adı: International Journal of Food Sciences and Nutrition
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CINAHL, MEDLINE
  • Sayfa Sayıları: ss.910-919
  • Anahtar Kelimeler: BDNF, dietary fibre, metabolic parameters, obesity, val66met
  • Ankara Üniversitesi Adresli: Evet

Özet

The aim of this study was to investigate the association of BDNF Val66Met genotype with obesity markers and metabolic parameters in a Turkish population. The study data were collected with a questionnaire form. The questionnaire form included general information, anthropometric measurements, dietary intake, lifestyle factors and biochemical parameters. Genotyping of the Val66Met variant in the BDNF gene was performed by real-time polymerase chain reaction (PCR). Individuals with the AG+AA genotype showed differences in obesity and metabolic parameters compared to GG homozygotes. Additionally, individuals with the AG+AA genotype showed lower waist circumference (pinteraction = 0.04), waist-to-hip ratio (pinteraction = 0.003), and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR; pinteraction = 0.009) when consuming a high-fibre diet (>18 g/day) compared to GG homozygotes. The study highlights the influence of BDNF Val66Met genotype on obesity and metabolic parameters, with dietary fibre intake potentially modifying these effects.