Determination of Usnic Acid Responsive miRNAs in Breast Cancer Cell Lines

Kilic N., Islakoglu Y. O., BÜYÜK İ., GÜR DEDEOĞLU B., CANSARAN DUMAN D.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, vol.19, no.12, pp.1463-1472, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 12
  • Publication Date: 2019
  • Doi Number: 10.2174/1871520618666181112120142
  • Journal Name: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1463-1472
  • Keywords: microRNA, breast cancer, usnic acid, microarray, anti-proliferative effect, alternative therapeutic agent, CHEMICAL-COMPOSITION, LUNG-CANCER, LICHEN, HEDGEHOG, MICRORNAS, ANTIOXIDANT, EXPRESSION, BIOMARKERS, INHIBITORS, APOPTOSIS
  • Ankara University Affiliated: Yes

Abstract

Objective: Breast Cancer (BC) is the most common type of cancer diagnosed in women. A common treatment strategy for BC is still not available because of its molecular heterogeneity and resistance is developed in most of the patients through the course of treatment. Therefore, alternative medicine resources as being novel treatment options are needed to be used for the treatment of BC. Usnic Acid (UA) that is one of the secondary metabolites of lichens used for different purposes in the field of medicine and its anti-proliferative effect has been shown in certain cancer types, suggesting its potential use for the treatment.