Umbilical cord mesenchymal stromal cells engraft and transdifferentiate into cardiomyocyte-like cells following acute myocardial ischemia

YIĞMAN Z., Ozdemir E. D., Turan N. N., Ulus A. T., CAN A.

ACTA HISTOCHEMICA, cilt.122, sa.6, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 122 Sayı: 6
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.acthis.2020.151578
  • Dergi Adı: ACTA HISTOCHEMICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Communication Abstracts, EMBASE, MEDLINE, Metadex, Civil Engineering Abstracts
  • Anahtar Kelimeler: Cardiac regeneration, Cell therapy, Myocardial ischemia, Human umbilical cord-derived mesenchymal stromal cells, Rat, STEM-CELLS, CARDIAC-FUNCTION, INTRACORONARY INFUSION, PHASE 1/2, REGENERATION, EFFICACY, REPAIR, MODEL, REVASCULARIZATION, TRANSPLANTATION
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective: Human umbilical cord-derived mesenchymal stromal cells (hUC-MSCs) gained importance in acute/chronic ischemic cardiomyopathy because of their outstanding regenerative potential in various pathologic conditions. The present study was designed to determine to what extent hUC-MSCs contribute to myocardial regeneration in acute experimental myocardial infarction (MI) in rats.