Expression of p53 protein in pterygium

Onur C., Orhan D., Orhan M., SAK S., Tulunay O., Irkec M.

EUROPEAN JOURNAL OF OPHTHALMOLOGY, cilt.8, sa.3, ss.157-161, 1998 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 3
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1177/112067219800800307
  • Dergi Adı: EUROPEAN JOURNAL OF OPHTHALMOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.157-161
  • Anahtar Kelimeler: pterygium, pathogenesis, tumor suppressor genes, p53 protein, TUMOR-SUPPRESSOR GENE, ULTRAVIOLET-RADIATION, DNA DAMAGE, CELLS, TUMORIGENESIS, EPITHELIUM, LECTURE, CANCER
  • Ankara Üniversitesi Adresli: Evet

Özet

Purpose. The pathogenesis of pterygium is still not completely understood and many environmental factors, including ultraviolet (UV) radiation, play an important role in its etiology. Chronic exposure to UV radiation causes mutations in the p53 tumor suppressor gene, eventually leading to tumor formation. We analyzed the immunohistochemical expression of p53 proteins in pterygial tissues to determine the role of the p53 tumor suppressor gene in the development of pterygium.