The Cellular Uptake and Apoptotic Efficiency of Colchicine is Correlated with Down-regulation of MMP-9 mRNA Expression in SW480 Colon Cancer Cells

ÖZMEN N., KAYA SEZGİNER E., BAKAR ATEŞ F.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, cilt.18, sa.13, ss.1927-1933, 2018 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 13
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2174/1871520618666180821102047
  • Dergi Adı: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1927-1933
  • Anahtar Kelimeler: Colchicine, cellular uptake, cytotoxicity, SW480, apoptosis, cell cycle, MMP-9, NF-KAPPA-B, MATRIX-METALLOPROTEINASE INHIBITORS, DEGRADATION, THERAPY, TARGET, ACID
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: Colchicine, a tricyclic alkaloid, is commonly used in treatment due to its anti-inflammatory and anti-fibrotic effects. Besides its toxicity at high doses, colchicine is reported for its potential anticancer effects at lower concentrations. The present study aimed to evaluate the anticancer effects of colchicine in SW480 cells.