Peripheral blood T-lymphocyte and T-lymphocyte subset ratios before and after treatment in schizophrenia patients not taking antipsychotic medication

Baskak S. C., Ozsan H., BASKAK B., ÖZGÜVEN H., Kinikli G.

TURK PSIKIYATRI DERGISI, cilt.19, sa.1, ss.5-12, 2008 (SSCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 1
  • Basım Tarihi: 2008
  • Dergi Adı: TURK PSIKIYATRI DERGISI
  • Derginin Tarandığı İndeksler: Social Sciences Citation Index (SSCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.5-12
  • Anahtar Kelimeler: schizophrenic, immunity (cellular), T-lymphocytes, flow-cytometry, PSYCHIATRIC-DISORDERS, CELL SUBSETS, SERUM-LEVELS, IMMUNITY, NEUROLEPTICS, POPULATIONS, RECEPTOR, SYSTEM
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective: Immune system abnormalities in schizophrenia have been previously studied. According to the present point of view, an infection or autoimmune process might be occurring in the form of cellular and/or humoral immune system abnormalities in schizophrenia. Furthermore, several effects of antipsychotic medication on the immunological profile of schizophrenic patients have been demonstrated. The present study aimed to compare the total T-lymphocytes level and the T-lymphocyte subset ratios in schizophrenia patients not treated with antipsychotics and healthy controls. The relationship between disease duration, symptom severity, and treatment response and T-lymphocyte profiles were investigated.