Peripheral blood T-lymphocyte and T-lymphocyte subset ratios before and after treatment in schizophrenia patients not taking antipsychotic medication
TURK PSIKIYATRI DERGISI, vol.19, no.1, pp.5-12, 2008 (SSCI, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 19 Issue: 1
- Publication Date: 2008
- Journal Name: TURK PSIKIYATRI DERGISI
- Journal Indexes: Social Sciences Citation Index (SSCI), Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.5-12
- Keywords: schizophrenic, immunity (cellular), T-lymphocytes, flow-cytometry, PSYCHIATRIC-DISORDERS, CELL SUBSETS, SERUM-LEVELS, IMMUNITY, NEUROLEPTICS, POPULATIONS, RECEPTOR, SYSTEM
- Ankara University Affiliated: Yes
Abstract
Objective: Immune system abnormalities in schizophrenia have been previously studied. According to the present point of view, an infection or autoimmune process might be occurring in the form of cellular and/or humoral immune system abnormalities in schizophrenia. Furthermore, several effects of antipsychotic medication on the immunological profile of schizophrenic patients have been demonstrated. The present study aimed to compare the total T-lymphocytes level and the T-lymphocyte subset ratios in schizophrenia patients not treated with antipsychotics and healthy controls. The relationship between disease duration, symptom severity, and treatment response and T-lymphocyte profiles were investigated.