Atıf İçin Kopyala
Kilicaslan D. Y., Cumaogullari O., Emiral E., Tezer N., Öncü Çetinkaya B., Özdağ Sevgili H., ...Daha Fazla
JOURNAL OF MENS HEALTH, cilt.18, 2022 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
18
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Basım Tarihi:
2022
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Doi Numarası:
10.31083/jomh.2021.116
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Dergi Adı:
JOURNAL OF MENS HEALTH
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Anahtar Kelimeler:
Suicide, Polymorphism, KASP, TPH-1, TPH-2, SEROTONIN TRANSPORTER GENE, SINGLE-NUCLEOTIDE POLYMORPHISMS, SHORT-TERM RISK, DEPRESSIVE DISORDER, HAPLOTYPE ANALYSIS, FAMILY-HISTORY, LIFE STRESS, ASSOCIATION, BEHAVIOR, CHILDHOOD
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Ankara Üniversitesi Adresli:
Evet
Özet
Background and objective: Serotonin plays an important role in the pathophysiology of aggressive behavior. Low serotonin levels and altered functions of serotonin receptors affect suicidal behavior. TPH-1, TPH-2 and SLC6A4 genes have important roles in serotonin production and degradation pathways. In this study, polymorphic variants of the TPH-1, TPH-2 and SLC6A4 genes, rs1800532, rs7305115, rs6355 and rs1386494, were investigated in 100 completed suicides and 100 healthy individuals.