Perturbation of HSP Network in MCF-7 Breast Cancer Cell Line Triggers Inducible HSP70 Expression and Leads to Tumor Suppression

ERGÜL M., AKTAN F., Yildiz M. T., Tutar Y.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, vol.20, no.9, pp.1051-1060, 2020 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 9
  • Publication Date: 2020
  • Doi Number: 10.2174/1871520620666200213102210
  • Journal Name: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.1051-1060
  • Keywords: HSP70, pifithrin-mu, PCR array, human breast cancer cell, ELISA, PES induction, AURORA-B, SURVIVIN EXPRESSION, APOPTOSIS, INHIBITOR, PROSTATE, PARP-1, OVEREXPRESSION, BIOLOGY, FAMILY, DRUGS
  • Ankara University Affiliated: Yes

Abstract

Background: Heat shock protein 70 (HSP70) is constitutively expressed in normal cells but aberrantly expressed in several types of tumor cells, helping their survival in extreme conditions. Thus, specific inhibition of HSP70 in tumor cells is a promising strategy in the treatment of cancer. HSP70 has a variety, of isoforms in the cellular organelles and form different functions by co-ordinating and cooperating with co chaperones. Cancer cells overexpress HSPs during cell growth and proliferation and HSP network provides resistance against apoptosis. The present study aimed to evaluate quantitative changes in HSPs- and cancer-associated gene expressions and their interactions in the presence of 2-phenylethyenesulfonamide (PES) in MCF-7 cells.