Effects of Arbutin on Fatty Acid Levels of Erythrocyte and Serum in Wistar Albino Rats Treated with Potassium Bromate

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AKKOYUN H. T., AYDIN S., AKKOYUN M. B., BENGÜ A. Ş., Ekin S., ASLAN ERDEM S.

INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH, vol.56, no.3, pp.740-747, 2022 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 3
  • Publication Date: 2022
  • Doi Number: 10.5530/ijper.56.3.123
  • Journal Name: INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
  • Page Numbers: pp.740-747
  • Keywords: Arbutin (ARB), Potassium bromate (KBrO3), Fatty acid (FA), Polyunsaturated fatty acids (PUFA), Monounsaturated fatty acids (MUFA), Wistar Albino Rat, INDUCED KIDNEY DAMAGE, OXIDATIVE STRESS, LIPID-PEROXIDATION, INDUCED APOPTOSIS, TOXICITY, PROTECTS, CARCINOGENICITY, BIOSYNTHESIS, RESVERATROL, IMPAIRMENT
  • Open Archive Collection: AVESIS Open Access Collection
  • Ankara University Affiliated: Yes

Abstract

Background: In the presented study; the Effects of Arbutin (ARB) on the Rat Erythrocyte and serum fatty acid profile which is exposed to potassium bromate (KBrO3) were investigated. Materials and Methods: In this study, 32 Wistar albino rats weighing 250-300 g were used divided into 4 groups. Groups 1: control, group 2: KBrO3 (single dose 100 mg / kg gavage), group 3: ARB (50 mg / kg / day (ip) for 5 days), group 4: KBrO3 + ARB. At the end of the 5(th) day, alteration of fatty acid profile in erythrocyte and serum of rats in all groups was examined. Results: Rat serum essential fatty acid; palmitic acid (C16:0), myristic acid (C14:0), stearic acid (C18:0), oleic acid (C18:1), linoleic acid (C18:2), erythrocyte major fatty acids; palmitic acid (C16:0), myristic acid (C14:0), stearic acid (C18:0), oleic acid (C18:1), linoleic acid (C18:2), arachidic acid (C20:0), eicosenoic acid (C20:1), and lignoceric acid (C24:0). In addition, in our studied serum and erythrocytes; Total monounsaturated fatty acids (MUFA) varied between 8.91 +/- 0.53- 11.71 +/- 2.55 and 33.71 +/- 2.12- 37.11 +/- 2.12, respectively. It was determined that total polyunsaturated fatty acids (PUFA) varied between 5.90 +/- 1.29- 9.96 +/- 1.18 and 14.72 +/- 3.66- 22.13 +/- 4.82, respectively. Conclusion: In our study, alterations in fatty acid contents were observed, and results suggesting that arbutine affects the enzymes involved in Fatty acid metabolism and has an effect on fatty acid amounts.