Synthesis and microbiological activity of some novel N-[2-(p-substitutedphenyl)-5-benzoxazolyl]-cyclohexyl carboxamide, -cyclohexyl acetamide and -cyclohexyl propionamide derivatives

Arpaci O., Sener E., Yalcin I., Altanlar N.

FARMACO, cilt.57, sa.9, ss.771-775, 2002 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Sayı: 9
  • Basım Tarihi: 2002
  • Dergi Adı: FARMACO
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Index Chemicus (IC)
  • Sayfa Sayıları: ss.771-775
  • Anahtar Kelimeler: 5-amide-substituted benzoxazoles, antibacterial activity, antifungal activity
  • Ankara Üniversitesi Adresli: Evet

Özet

The synthesis and microbiological activity of a new series of N-[2-(p-substituted phenyl)-5-benzoxazolyl]-cyclohexyl carboxamide, -cyclohexyl acetamide and -cyclohexyl propionamide derivatives (4-11) is described. The in vitro microbiological activity of the compounds was determined against Gram-positive, Gram-negative bacteria and the yeast Candida albicans in comparison with standard drugs. Microbiological results indicated that the synthesized compounds possessed a broad spectrum of activity against the tested microorganisms. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.