An Efficient Synthetic Method for the Synthesis of Novel Pyrimido[1,2-a]Pyrimidine-3-Carboxylates: Comparison of Irradiation and Conventional Conditions

BAYRAMOĞLU D., GÜLLÜ M.

POLYCYCLIC AROMATIC COMPOUNDS, cilt.42, sa.8, ss.4948-4964, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 8
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1080/10406638.2021.1915806
  • Dergi Adı: POLYCYCLIC AROMATIC COMPOUNDS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Applied Science & Technology Source, CAB Abstracts, Chemical Abstracts Core, Communication Abstracts, Food Science & Technology Abstracts, Metadex, Pollution Abstracts, Veterinary Science Database, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.4948-4964
  • Anahtar Kelimeler: Pyrimido[1, 2-a]pyrimidine, 2-aminopyrimidine, multicomponent reactions, microwave assisted reactions, quinolones antibiotics, PYRIMIDINE, DERIVATIVES
  • Ankara Üniversitesi Adresli: Evet

Özet

A very simple and efficient procedure for the synthesis of novel pyrimido[1,2-a]pyrimidine derivatives is described. Thermal cyclization reactions of 2-aminopyrimidine and its substituted derivatives with diethyl ethoxymethylenemalonate (EMME) have been investigated. Conventional heating and microwave irradiation (MW) conditions were applied to enable the comparison of both techniques on the obtained products. Besides the effect of different reaction parameters and the substituents on the conversion reactions have been also investigated in detail. Structural analyses of all compounds synthesized with high yields have been carried out by suitable spectroscopic methods (FT-IR, NMR, mass spectroscopy, LC-MS TOF).