The syntheses, crystal structure, thermal analysis, and anticancer activities of novel dipicolinate complexes

Uzun N., ÇOLAK A. T., EMEN F. M., KISMALI G., MERAL Ö., Alpay M., ...Daha Fazla

JOURNAL OF COORDINATION CHEMISTRY, cilt.68, sa.6, ss.949-967, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 68 Sayı: 6
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1080/00958972.2014.1003371
  • Dergi Adı: JOURNAL OF COORDINATION CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.949-967
  • Anahtar Kelimeler: 2, 6-Pyridinedicarboxylate, Crystal structure, Thermal analysis, Anticancer activities, ONE-DIMENSIONAL CHANNELS, COORDINATION POLYMERS, PYRIDINE-2,6-DICARBOXYLIC ACID, COPPER(II) COMPLEXES, ZINC(II) COMPLEXES, METAL-COMPLEXES, ANTICONVULSANT ACTIVITIES, CARCINOMA-CELLS, HYDROGEN-BONDS, LIGANDS
  • Ankara Üniversitesi Adresli: Evet

Özet

[Cu(pydc)(eim)(3)].H2O (1), [Cu(pydc)(4hp)(H2O)] (2), and [Ni(pydc)(3hp)(H2O)(2)][Cu(pydc)(3hp)(H2O)(2)].3H(2)O (3) (H(2)pydc=2,6-pyridinedicarboxylic acid or dipicolinic acid, eim=2-ethylimidazole, 4hp=4-hydroxypyridine, 3hp=3-hydroxypyridine) were synthesized and characterized by elemental analysis, spectroscopic measurements (UV-vis and IR spectra), and single-crystal X-ray diffraction. Crystal analysis revealed that the complexes extended to 3-D supramolecular networks through intermolecular H-bonding and molecular interactions between the ligand moieties and water molecules. The thermal stabilities of complexes are investigated by thermogravimetry, differential thermogravimetry, and differential thermal analysis techniques. The effects of complexes on the proliferation of HT-1080 fibrosarcoma cells were investigated using the quick cell proliferation assay. The cell viability changes were found to depend on the concentrations and type of complex.