Involvement of 5-HT1B and 5-HT1D receptors in sumatriptan mediated vasocontractile response in rabbit common carotid artery

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Akin D., GÜRDAL H.

BRITISH JOURNAL OF PHARMACOLOGY, vol.136, no.2, pp.177-182, 2002 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 136 Issue: 2
• Publication Date: 2002
• Doi Number: 10.1038/sj.bjp.0704709
• Journal Name: BRITISH JOURNAL OF PHARMACOLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.177-182
• Keywords: sumatriptan, vascular contractions, serotonin, inositol phosphate accumulation, cyclic AMP, voltage-dependent calcium channels, Gi/o proteins, 5-HT1B receptors, 5-HT1D receptors, rabbit common carotid artery, SAPHENOUS-VEIN, CEREBRAL-ARTERIES, BLOOD-VESSELS, MESSENGER-RNA, EXPRESSION, DIMERIZATION, INHIBITION, ELEVATION, SUBTYPE, CYCLASE
• Ankara University Affiliated: Yes

Abstract

1 In this study we examined the involvement of 5-HT1B and 5-HT1D receptors in the vasocontractile response induced by 5-HT1B/D-receptor agonist sumatriptan in rabbit common carotid artery (CCA).