COMPARISON OF PHARMACOLOGIC DELAY OPERATION BY LOCAL VEGF INJECTION WITH OTHER SURGICAL DELAY PROCEDURES ON RAT DORSAL SKIN FLAP

Demirel M., HEPER A., Yormuk E.

TURKISH JOURNAL OF PLASTIC SURGERY, vol.18, no.1, pp.24-30, 2010 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 1
  • Publication Date: 2010
  • Journal Name: TURKISH JOURNAL OF PLASTIC SURGERY
  • Journal Indexes: Emerging Sources Citation Index (ESCI)
  • Page Numbers: pp.24-30
  • Ankara University Affiliated: Yes

Abstract

VEGF is a potent angiogenetic factor. It also enhances capillary permeability. Its production rises endogeniously in ischemic conditions. It is known that exogenous VEGF injections protect the tissue against ischemia reperfusion injury and also has a pharmacological delay effect. Clinical experimental studies showed that surgical delay procedures enhance skin and muscle-skin flap survival.